Agents to reduce cytokine storm
نویسندگان
چکیده
منابع مشابه
Agents to reduce cytokine storm
The increasing insight into pathomechanisms of dysregulated host response in several inflammatory diseases led to the implementation of the term "cytokine storm" in the literature more than 20 years ago. Direct toxic effects as well as indirect immunomodulatory mechanisms during cytokine storm have been described and were the basis for the rationale to use several substances and devices in life...
متن کاملDynamics of a Cytokine Storm
Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response. Soon after the trial began, each volunteer experienced a "cytokine storm", a dramatic increase in cytokine concentrations. The monoclonal antibody, TGN1412, raised serum concentrations of both pro- and anti-inflammatory c...
متن کاملTargeting the "cytokine storm" for therapeutic benefit.
Inflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacterium Francisella tularensis, do trigger life-threatening "cytokine storms...
متن کاملSystemic cytokine storm in severe eosinophilic dermatitis.
A 27-year-old woman presented with a 12-day history of worsening fever and rash. Erythematous, indurated and pruritic lesions had been developing on her inner thighs. They went on to spread to her arms and back. She was previously fit and well with no relevant past medical or family history. During her first week in hospital, she became intermittently confused and disorientated and was also int...
متن کاملA New Shield for a Cytokine Storm
Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network.
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ژورنال
عنوان ژورنال: F1000Research
سال: 2016
ISSN: 2046-1402
DOI: 10.12688/f1000research.9092.1